The Town Museum is located in the Palazzo del Podestà and in the Palazzo Biancalana. The collection includes two different sections: the archaeological section and the Art Gallery. In the archaeological section, the Etruscan and Roman finds testify the origins of Bettona territory.

Among the most important works is the magnificent marble head of Aphrodite dating back to the middle imperial age. The artistic tour continues with the Art Gallery where, among the numerous paintings, the Madonna della Misericordia by Perugino stands out together with other masterpieces by great artists such as Dono Doni, El Greco and Jacopo Siculo.